Literature summary for 2.5.1.15 extracted from

Chotpatiwetchkul, W.; Boonyarattanakalin, K.; Gleeson, D.; Gleeson, M.P.
Exploring the catalytic mechanism of dihydropteroate synthase elucidating the differences between the substrate and inhibitor (2017), Org. Biomol. Chem., 15, 5593-5601 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate	Yersinia pestis	-	diphosphate + 7,8-dihydropteroate	-	?

Organism

Organism	UniProt	Comment	Textmining
Yersinia pestis	A0A384KP04	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate	-	Yersinia pestis	diphosphate + 7,8-dihydropteroate	-	?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate	mechanistic proposals for dihydropteroate synthase have been systematically investigated using a hybrid QM/MM method. A reaction mechanism is proposed that follows an SN1 process with the rate determining step being C-O bond breaking to give a carbocation intermediate	Yersinia pestis	diphosphate + 7,8-dihydropteroate	-	?

Synonyms

Synonyms	Comment	Organism
DHPS	-	Yersinia pestis

General Information

General Information	Comment	Organism
drug target	target for anti-malarial and anti-bacterial drugs	Yersinia pestis

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Release 2023.1 (January 2023)