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Literature summary for 2.5.1.15 extracted from

  • Nasr, T.; Bondock, S.; Ibrahim, T.M.; Fayad, W.; Ibrahim, A.B.; AbdelAziz, N.A.; Sakr, T.M.
    New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors (2020), Bioorg. Med. Chem., 28, 115444 .
    View publication on PubMed
Search for more literature for 2.5.1.15

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Bacillus subtilis
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Escherichia coli
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Streptococcus pneumoniae
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Syncephalastrum racemosum
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(ethylthio)-acrylamide
-
 Bacillus subtilis
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(ethylthio)-acrylamide
-
 Escherichia coli
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(ethylthio)-acrylamide
-
 Streptococcus pneumoniae
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-(ethylthio)-acrylamide
-
 Syncephalastrum racemosum
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-mercapto-acrylamide
-
 Bacillus subtilis
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-mercapto-acrylamide
-
 Escherichia coli
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-mercapto-acrylamide
-
 Streptococcus pneumoniae
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylamino)-3-mercapto-acrylamide
-
 Syncephalastrum racemosum
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(methylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Bacillus subtilis
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(methylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Escherichia coli
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(methylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Streptococcus pneumoniae
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(methylamino)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Syncephalastrum racemosum
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-mercapto-3-(methylamino)acrylamide
-
 Bacillus subtilis
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-mercapto-3-(methylamino)acrylamide
-
 Escherichia coli
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-mercapto-3-(methylamino)acrylamide
-
 Streptococcus pneumoniae
(E)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-mercapto-3-(methylamino)acrylamide
-
 Syncephalastrum racemosum
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl) amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosylthio)acrylamide
-
 Escherichia coli
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl) amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosylthio)acrylamide
-
 Streptococcus pneumoniae
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl) amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosylthio)acrylamide
-
 Syncephalastrum racemosum
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosylthio)acrylamide
-
 Bacillus subtilis
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Bacillus subtilis
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Escherichia coli
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Streptococcus pneumoniae
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosylthio)acrylamide
-
 Syncephalastrum racemosum
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylthio)-acrylamide
-
 Bacillus subtilis
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylthio)-acrylamide
-
 Escherichia coli
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylthio)-acrylamide
-
 Streptococcus pneumoniae
(E)-3-(allylamino)-2-cyano-N-(4-[[(3,4-dimethylisoxazol-5-yl)amino]sulfonyl]phenyl)-3-(ethylthio)-acrylamide
-
 Syncephalastrum racemosum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Bacillus subtilis
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Escherichia coli
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Streptococcus pneumoniae
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Proteus vulgaris
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Syncephalastrum racemosum
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Yersinia pestis
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Yersinia pestis KIM D27
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Escherichia coli ATCC 25922
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Escherichia coli
-
-
-
Escherichia coli ATCC 25922
-
-
-
Proteus vulgaris
-
-
-
Streptococcus pneumoniae
-
-
-
Syncephalastrum racemosum
-
-
-
Yersinia pestis A0A384KP04
-
-
Yersinia pestis KIM D27 A0A384KP04
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Bacillus subtilis diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Escherichia coli diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Streptococcus pneumoniae diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Proteus vulgaris diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Syncephalastrum racemosum diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Yersinia pestis diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Yersinia pestis KIM D27 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Escherichia coli ATCC 25922 diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

Synonyms Comment Organism
DHPS
-
 Bacillus subtilis
DHPS
-
 Escherichia coli
DHPS
-
 Streptococcus pneumoniae
DHPS
-
 Proteus vulgaris
DHPS
-
 Syncephalastrum racemosum
DHPS
-
 Yersinia pestis