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Literature summary for 2.5.1.15 extracted from

  • Capasso, C.; Supuran, C.T.
    Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors (2014), J. Enzyme Inhib. Med. Chem., 29, 379-387.
    View publication on PubMed
Search for more literature for 2.5.1.15

Inhibitors

Inhibitors Comment Organism Structure
sulfacetamide competitive inhibitor Bacillus anthracis
sulfacetamide competitive inhibitor Yersinia pestis
sulfamethoxazole competitive inhibitor Bacillus anthracis
sulfamethoxazole competitive inhibitor Yersinia pestis
sulfathiazole competitive inhibitor Bacillus anthracis
sulfathiazole competitive inhibitor Yersinia pestis
sulfisomidine competitive inhibitor Bacillus anthracis
sulfisomidine competitive inhibitor Yersinia pestis
sulfonamide competitive inhibitor Bacillus anthracis
sulfonamide competitive inhibitor Yersinia pestis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Yersinia pestis
-
 diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate Bacillus anthracis
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-
Yersinia pestis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Yersinia pestis diphosphate + 7,8-dihydropteroate
-
 ?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
-
 Bacillus anthracis diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

Synonyms Comment Organism
DHP synthase
-
 Yersinia pestis
DHP synthase
-
 Bacillus anthracis
DHPS
-
 Yersinia pestis
DHPS
-
 Bacillus anthracis