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Literature summary for 2.5.1.15 extracted from

  • Raman, J.; Sharp, B.; Kleinschmidt, I.; Roper, C.; Streat, E.; Kelly, V.; Barnes, K.I.
    Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern Mozambique (2008), Am. J. Trop. Med. Hyg., 78, 256-261.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
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-
-

Synonyms

Synonyms Comment Organism
DHPS
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 Plasmodium falciparum
dihydropteroate synthase
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 Plasmodium falciparum

General Information

General Information Comment Organism
malfunction prevalence and frequency of the dihydropteroate synthetase mutations associated with sulfadoxine-pyrimethamine resistance in southern Mozambique are examined between 1999 and 2004. The dihydropteroate synthetase double mutation frequency peaks in 2001 but declines to baseline levels by 2004. Parasites with both dihydrofolate reductase triple and dihydropteroate synthetase double mutations increase in 2001 but decrease by 2004. The peaking of sulfadoxine-pyrimethamine resistance markers in 2001 coincides with a sulfadoxine-pyrimethamine-resistant malaria epidemic in neighboring KwaZulu-Natal, South Africa. The decline in dihydropteroate synthetase (but not dihydrofolate reductase) mutations correspond with replacement of sulfadoxine-pyrimethamine with artemether-lumefantrine as malaria treatment policy in KwaZulu-Natal Plasmodium falciparum