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Literature summary for 2.5.1.15 extracted from

  • de Beer, T.A.; Louw, A.I.; Joubert, F.
    Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase (2006), Bioorg. Med. Chem., 14, 4433-4443.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
more putative structural model of five mutations in DHPS to explain sulfadoxine resistance, structural model based on crystal structures of Saccharomyces cerevisiae (PPPK-DHPS), Mycobacterium tuberculosis (DHPS), Bacillus anthracis (DHPS), and Escherichia coli (PPPK) Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
sulfadoxine
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Plasmodium falciparum
-
diphosphate + 7,8-dihydropteroate
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q27735 fragment of dihydropteroate synthase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Plasmodium falciparum diphosphate + 7,8-dihydropteroate
-
?

Synonyms

Synonyms Comment Organism
7,8-dihydropteroate synthase
-
Plasmodium falciparum
DHPS
-
Plasmodium falciparum
dihydropteroate synthetase
-
Plasmodium falciparum