BRENDA - Enzyme Database show
show all sequences of 2.5.1.147

Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis

Philmus, B.; Decamps, L.; Berteau, O.; Begley, T.; J. Am. Chem. Soc. 137, 5406-5413 (2015)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
Methanocaldococcus jannaschii
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
Methanocaldococcus jannaschii DSM 2661
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Methanocaldococcus jannaschii
Q58826
-
-
Methanocaldococcus jannaschii DSM 2661
Q58826
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
748030
Methanocaldococcus jannaschii
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
748030
Methanocaldococcus jannaschii
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
748030
Methanocaldococcus jannaschii DSM 2661
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
748030
Methanocaldococcus jannaschii DSM 2661
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
Methanocaldococcus jannaschii
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
Methanocaldococcus jannaschii DSM 2661
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
748030
Methanocaldococcus jannaschii
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
748030
Methanocaldococcus jannaschii
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
-
748030
Methanocaldococcus jannaschii DSM 2661
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
748030
Methanocaldococcus jannaschii DSM 2661
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine
-
-
-
?
General Information
General Information
Commentary
Organism
metabolism
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
Methanocaldococcus jannaschii
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420
Methanocaldococcus jannaschii
Other publictions for EC 2.5.1.147
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748030
Philmus
Biosynthetic versatility and ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661
J. Am. Chem. Soc.
137
5406-5413
2015
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748607
Guerra-Lopez
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Mycobacterium smegmatis mc2 1 ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc2 155
Microbiology
153
2724-2732
2007
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746934
Graham
Identification of the 7,8-did ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661, Mycolicibacterium smegmatis
Arch. Microbiol.
180
455-464
2003
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748075
Choi
Demonstration that fbiC is re ...
Mycobacterium tuberculosis variant bovis
J. Bacteriol.
184
2420-2428
2002
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