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Literature summary for 2.5.1.145 extracted from

  • Dautin, N.; Argentini, M.; Mohiman, N.; Labarre, C.; Cornu, D.; Sago, L.; Chami, M.; Dietrich, C.; de Sousa d'Auria, C.; Houssin, C.; Masi, M.; Salmeron, C.; Bayan, N.
    Role of the unique, non-essential phosphatidylglycerol prolipoprotein diacylglyceryl transferase (Lgt) in Corynebacterium glutamicum (2020), Microbiology, 166, 759-776 .
    View publication on PubMed
Search for more literature for 2.5.1.145

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine Corynebacterium glutamicum
-
 sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine Corynebacterium glutamicum RES167
-
 sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
-
-
Corynebacterium glutamicum RES167
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine
-
 Corynebacterium glutamicum sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
L-1-phosphatidyl-sn-glycerol + a [prolipoprotein]-L-cysteine
-
 Corynebacterium glutamicum RES167 sn-glycerol 1-phosphate + an [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
LGT
-
 Corynebacterium glutamicum
phosphatidylglycerol::prolipoprotein diacylglyceryl transferase
-
 Corynebacterium glutamicum

General Information

General Information Comment Organism
metabolism the enzyme is necessary for the acylation and membrane anchoring of two model lipoproteins expressed in Corynebacterium glutamicum: MusE, a C. glutamicum maltose-binding lipoprotein, and LppX, a Mycobacterium tuberculosis lipoprotein. However, the enzyme is not required for these proteins' signal peptide cleavage, or for LppX glycosylation. The enzyme is not necessary for growth on maltose Corynebacterium glutamicum