Literature summary for 2.5.1.140 extracted from

Kobylarz, M.J.; Grigg, J.C.; Takayama, S.J.; Rai, D.K.; Heinrichs, D.E.; Murphy, M.E.
Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor (2014), Chem. Biol., 21, 379-388.

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Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	A6QDA0	-	-
Staphylococcus aureus Newman	A6QDA0	-	-

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	during staphyloferrin B biosynthesis, SbnA uses pyridoxal 5'-phosphate and substrates O-phospho-L-serine and L-glutamate to produce a metabolite N-(1-amino-1-carboxyl-2-ethyl)-glutamic acid (ACEGA). SbnB uses NAD+ to oxidatively hydrolyze ACEGA to yield alphaoglutarate and L-2,3-diamnopropionic acid. SbnA and SbnB contribute to the iron sparing response of Staphylococcus aureus that enables staphyloferrin B biosynthesis in the absence of an active tricarboxylic acid cycle	Staphylococcus aureus

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Release 2023.1 (January 2023)