Literature summary for 2.5.1.122 extracted from

Fan, A.; Zocher, G.; Stec, E.; Stehle, T.; Li, S.M.
Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme (2015), J. Biol. Chem., 290, 1364-1373.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dimethylallyl diphosphate + L-tyrosine	Aspergillus fumigatus	-	diphosphate + 4-O-dimethylallyl-L-tyrosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dimethylallyl diphosphate + L-tyrosine	-	Aspergillus fumigatus	diphosphate + 4-O-dimethylallyl-L-tyrosine	-	?
additional information	the enzyme catalyzes C7-prenylation of the indole ring, EC 2.5.1.80, but also accepts L-tyrosine as substrate and converts it to an O-prenylated derivative, EC 2.5.1.122. 7-DMATS is able to take L-tyrosine and two derivatives thereof as substrates and catalyzed the same O- or N-prenylation	Aspergillus fumigatus	?	-	?

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Release 2023.1 (January 2023)