Literature summary for 2.5.1.108 extracted from

Dong, M.; Dando, E.; Kotliar, I.; Su, X.; Dzikovski, B.; Freed, J.; Lin, H.
The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis (2019), J. Biol. Inorg. Chem., 24, 777-782 .

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Protein Variants

Protein Variants	Comment	Organism
C106A	the mutant shows wild type activity	Saccharomyces cerevisiae
C128A	the mutant shows reduced activity compared to the wild type enzyme	Saccharomyces cerevisiae
C304A	the mutant shows wild type activity	Saccharomyces cerevisiae
C362A	the mutant shows reduced activity compared to the wild type enzyme	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]	Saccharomyces cerevisiae	-	S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	no activity is detected using dithionite or the Dph3/Cbr1/NADH system as the reductant	Saccharomyces cerevisiae	?	-	-
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]	-	Saccharomyces cerevisiae	S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]	-	?

Subunits

Subunits	Comment	Organism
heterodimer	1 * 60000 + 1 * 40000, SDS-PAGE	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
Dph1-Dph2	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
[4Fe-4S]-center	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)