Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2] | Saccharomyces cerevisiae | the enzyme is involved in diphthamide biosynthesis | S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2] | - |
? | |
S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2] | Mus musculus | the enzyme is involved in diphthamide biosynthesis | S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9CR25 | - |
- |
Saccharomyces cerevisiae | P32461 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2] | The relevant histidine of translation elongation factor 2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2] | the enzyme is involved in diphthamide biosynthesis | Saccharomyces cerevisiae | S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2] | - |
? | |
S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2] | the enzyme is involved in diphthamide biosynthesis | Mus musculus | S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dph2 | - |
Mus musculus |
Dph2 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | mutation in DPH2 blocks diphthamide biosynthesis | Saccharomyces cerevisiae |
physiological function | required for diphthamide biosynthesis | Mus musculus |
physiological function | the enzyme is involved in diphthamide biosynthesis | Mus musculus |
physiological function | the enzyme is involved in diphthamide biosynthesis | Saccharomyces cerevisiae |