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Literature summary for 2.5.1.102 extracted from
- Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol (1998), FEBS Lett., 427, 283-285.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics with geranyl diphosphate as substrate | Cannabis sativa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | essentially required | Cannabis sativa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate | Cannabis sativa | - |
diphosphate + cannabigerolate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cannabis sativa | - |
var. Skunk | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | young | Cannabis sativa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate | - |
Cannabis sativa | diphosphate + cannabigerolate | - |
? | |
| geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate | i.e. olivetolate | Cannabis sativa | diphosphate + cannabigerolate | - |
? | |
| additional information | the enzyme accepts geranyldiphosphate and to a lesser degree also neryldiphosphate as a cosubstrate. Olivetol is inactive as a prenyl acceptor, GOT is specific for olivetolic acid | Cannabis sativa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| geranylpyrophosphate:olivetolate geranyltransferase | - |
Cannabis sativa |
| GOT | - |
Cannabis sativa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Cannabis sativa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Cannabis sativa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | GOT is the first enzyme in the biosynthesis of DELTA1-tetrahydrocannabinolic acid and cannabinoids | Cannabis sativa |
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