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Literature summary for 2.5.1.10 extracted from

  • Gritzalis, D.; Park, J.; Chiu, W.; Cho, H.; Lin, Y.S.; De Schutter, J.W.; Lacbay, C.M.; Zielinski, M.; Berghuis, A.M.; Tsantrizos, Y.S.
    Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase (2015), Bioorg. Med. Chem. Lett., 25, 1117-1123.
    View publication on PubMed
Search for more literature for 2.5.1.10

Inhibitors

Inhibitors Comment Organism Structure
alendronic acid
-
 Homo sapiens
ibandronic acid
-
 Homo sapiens
minodronic acid
-
 Homo sapiens
pamidronic acid
-
 Homo sapiens
risedronic acid
-
 Homo sapiens
zoledronic acid
-
 Homo sapiens
[2-(1,2-dimethyl-1H-indol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) about 64% inhibition at 0.01 mM Homo sapiens
[2-(1-ethyl-1H-indol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) about 78% inhibition at 0.01 mM Homo sapiens
[2-(1-methyl-1H-indol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) about 60% inhibition at 0.01 mM Homo sapiens
[2-(2-methyl-1H-indol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) about 30% inhibition at 0.01 mM Homo sapiens
[2-(2-tert-butyl-1H-indol-3-yl)ethane-1,1-diyl]bis(phosphonic acid) about 79% inhibition at 0.01 mM Homo sapiens
{2-[(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]ethane-1,1-diyl}bis(phosphonic acid) about 65% inhibition at 0.01 mM Homo sapiens
{2-[(3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)amino]ethane-1,1-diyl}bis(phosphonic acid) about 10% inhibition at 0.01 mM Homo sapiens
{2-[1-(propan-2-yl)-1H-indol-3-yl]ethane-1,1-diyl}bis(phosphonic acid) about 45% inhibition at 0.01 mM Homo sapiens
{2-[2-(1-cyclopentylethyl)-1H-indol-3-yl]ethane-1,1-diyl}bis(phosphonic acid) about 90% inhibition at 0.01 mM Homo sapiens
{2-[2-(3-methylbutan-2-yl)-1H-indol-3-yl]ethane-1,1-diyl}bis(phosphonic acid) about 85% inhibition at 0.01 mM Homo sapiens
{2-[2-(3-methylbutan-2-yl)-5-phenyl-1H-indol-3-yl]ethane-1,1-diyl}bis(phosphonic acid) about 95% inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate Homo sapiens
-
 diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14324
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate
-
 Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
farnesyl pyrophosphate synthase
-
 Homo sapiens
FPPS
-
 Homo sapiens