BRENDA - Enzyme Database show
show all sequences of 2.5.1.10

Partial purification and characterization of the short-chain prenyltransferases, gernayl diphospate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir)

Tholl, D.; Croteau, R.; Gershenzon, J.; Arch. Biochem. Biophys. 386, 233-242 (2001)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
not activated by Tween 20, Triton X-100, Chaps or Nonidet P-40
Abies grandis
Inhibitors
Inhibitors
Commentary
Organism
Structure
diphosphate
0.66 mM, 50% inhibition
Abies grandis
farnesyl diphosphate
0.06 mM, 50% inhibition
Abies grandis
K+
500 mM, 63% inhibition in the presence of MgCl2
Abies grandis
Mn2+
strong inhibition above 0.1 mM, activation below
Abies grandis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0018
-
geranyl diphosphate
-
Abies grandis
0.009
-
dimethylallyl diphosphate
-
Abies grandis
0.0153
-
isopentenyl diphosphate
-
Abies grandis
0.0445
-
Mn2+
-
Abies grandis
0.0712
-
Mg2+
-
Abies grandis
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
18% of Mg2+ activation at 0.5 mM, inhibition above
Abies grandis
Co2+
78% of Mg2+ activation at 1 mM
Abies grandis
Mg2+
maximal activity at 1 mM; required for activity
Abies grandis
Mn2+
can replace Mg2+, maximal activity at 0.1 mM, inhibition above
Abies grandis
Ni2+
10% of Mg2+ activation at 0.5 mM, inhibition above
Abies grandis
Zn2+
91% of Mg2+ activation at 0.5 mM, almost complete inhibition at 5 mM
Abies grandis
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
110000
-
gel filtration
Abies grandis
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Abies grandis
-
grand fir
-
Purification (Commentary)
Commentary
Organism
DEAE-Sepharose, Mono Q, phenyl-Sepharose
Abies grandis
Source Tissue
Source Tissue
Commentary
Organism
Textmining
sapling
-
Abies grandis
-
Storage Stability
Storage Stability
Organism
-80C, 3 months, no loss of activity
Abies grandis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dimethylallyl diphosphate + 2 isopentenyl diphosphate
-
638706
Abies grandis
(E,E)-farnesyl diphosphate + 2 diphosphate
-
638706
Abies grandis
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8
-
Abies grandis
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
not activated by Tween 20, Triton X-100, Chaps or Nonidet P-40
Abies grandis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
diphosphate
0.66 mM, 50% inhibition
Abies grandis
farnesyl diphosphate
0.06 mM, 50% inhibition
Abies grandis
K+
500 mM, 63% inhibition in the presence of MgCl2
Abies grandis
Mn2+
strong inhibition above 0.1 mM, activation below
Abies grandis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0018
-
geranyl diphosphate
-
Abies grandis
0.009
-
dimethylallyl diphosphate
-
Abies grandis
0.0153
-
isopentenyl diphosphate
-
Abies grandis
0.0445
-
Mn2+
-
Abies grandis
0.0712
-
Mg2+
-
Abies grandis
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
18% of Mg2+ activation at 0.5 mM, inhibition above
Abies grandis
Co2+
78% of Mg2+ activation at 1 mM
Abies grandis
Mg2+
maximal activity at 1 mM; required for activity
Abies grandis
Mn2+
can replace Mg2+, maximal activity at 0.1 mM, inhibition above
Abies grandis
Ni2+
10% of Mg2+ activation at 0.5 mM, inhibition above
Abies grandis
Zn2+
91% of Mg2+ activation at 0.5 mM, almost complete inhibition at 5 mM
Abies grandis
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
110000
-
gel filtration
Abies grandis
Purification (Commentary) (protein specific)
Commentary
Organism
DEAE-Sepharose, Mono Q, phenyl-Sepharose
Abies grandis
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
sapling
-
Abies grandis
-
Storage Stability (protein specific)
Storage Stability
Organism
-80C, 3 months, no loss of activity
Abies grandis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dimethylallyl diphosphate + 2 isopentenyl diphosphate
-
638706
Abies grandis
(E,E)-farnesyl diphosphate + 2 diphosphate
-
638706
Abies grandis
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8
-
Abies grandis
Other publictions for EC 2.5.1.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737926
Sharifirad
Characterization of a farnesyl ...
Penicillium brevicompactum, Penicillium brevicompactum MUCL 19011
Biotechnol. Lett.
38
71-79
2016
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1
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738477
Deng
Enhanced (S)-linalool producti ...
Actinidia arguta
J. Appl. Microbiol.
121
187-195
2016
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1
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1
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737359
Schmidberger
Structural characterization of ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
71
721-731
2015
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1
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737821
Gritzalis
Probing the molecular and stru ...
Homo sapiens
Bioorg. Med. Chem. Lett.
25
1117-1123
2015
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17
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1
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1
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17
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1
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1
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738069
Marzinzik
Discovery of novel allosteric ...
Homo sapiens
ChemMedChem
10
1884-1891
2015
-
-
-
-
-
-
26
-
-
-
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1
-
1
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1
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23
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23
26
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1
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1
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738331
Su
Cloning and characterization o ...
Matricaria chamomilla var. recutita
Genet. Mol. Res.
14
349-361
2015
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1
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6
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1
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1
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1
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739384
Richter
A small, differentially regula ...
Zea mays
Planta
241
1351-1361
2015
-
-
-
-
-
-
-
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2
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4
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1
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1
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739414
Zhao
Molecular cloning and characte ...
Tripterygium wilfordii
PLoS ONE
10
e0125415
2015
-
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1
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6
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2
2
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1
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2
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739656
Ferriols
Cloning and characterization o ...
Rhizosolenia setigera, Rhizosolenia setigera CCMP1694
Sci. Rep.
5
10246
2015
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1
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6
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1
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4
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1
1
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737349
Aripirala
Structural and thermodynamic b ...
Leishmania major
Acta Crystallogr. Sect. D
70
802-810
2014
-
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1
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4
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1
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5
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737749
Das
Upregulation of endogenous far ...
Homo sapiens
Biochim. Biophys. Acta
1841
569-573
2014
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739513
Alcaino
Functional characterization of ...
Xanthophyllomyces dendrorhous, Xanthophyllomyces dendrorhous ATCC 24230
PLoS ONE
9
e96626
2014
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739542
Liu
Taxodione and arenarone inhibi ...
Homo sapiens, Trypanosoma brucei
Proc. Natl. Acad. Sci. USA
111
E2530-E2539
2014
-
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1
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17
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4
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4
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16
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16
17
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723664
Frick
Metal ions control product spe ...
Phaedon cochleariae
Proc. Natl. Acad. Sci. USA
110
4194-4199
2013
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737833
Leung
Discovery of thienopyrimidine- ...
Homo sapiens
Bioorg. Med. Chem.
21
2229-2240
2013
-
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7
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721671
Li
The N-terminus and the chain-l ...
Toxoplasma gondii, Toxoplasma gondii RH
Biochemistry
51
7533-7540
2012
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722094
Demoro
Bisphosphonate metal complexes ...
Trypanosoma cruzi
Dalton Trans.
41
6468-6476
2012
-
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15
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15
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15
15
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722923
Aripirala
Design, synthesis, calorimetry ...
Trypanosoma cruzi
J. Med. Chem.
55
6445-6454
2012
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1
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11
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4
11
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723003
Nagaki
-
Substrate specificities of E- ...
Geobacillus stearothermophilus, Geobacillus stearothermophilus ATCC 10149
J. Mol. Catal. B
80
1-6
2012
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1
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1
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723709
Sun
In silico and in vitro analyse ...
Rhopalosiphum padi
Protein J.
31
417-424
2012
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3
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1
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2
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721830
Rosso
Synthesis and biological evalu ...
Toxoplasma gondii, Trypanosoma cruzi
Bioorg. Med. Chem.
19
2211-2217
2011
-
1
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24
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4
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2
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2
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Farnesyl diphosphate synthase; ...
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3
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2
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1
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1968
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5
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