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show all sequences of 2.4.99.4

Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity

Huang, S.; Day, T.W.; Choi, M.R.; Safa, A.R.; Mol. Cell. Biochem. 331, 81-88 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
drug development
ST3Gal III can serve as a therapeutic target of taxol therapy
Homo sapiens
Cloned(Commentary)
Commentary
Organism
full-length ST3Gal III DNA fragment subcloned into the pEF6/V5-His TOPO expression vector. SKOV-3 cells transfected with ST3Gal III-EF6
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
SKOV-3 cell
expresses little ST3Gal III protein
Homo sapiens
-
Application (protein specific)
Application
Commentary
Organism
drug development
ST3Gal III can serve as a therapeutic target of taxol therapy
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
full-length ST3Gal III DNA fragment subcloned into the pEF6/V5-His TOPO expression vector. SKOV-3 cells transfected with ST3Gal III-EF6
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
SKOV-3 cell
expresses little ST3Gal III protein
Homo sapiens
-
Expression
Organism
Commentary
Expression
Homo sapiens
taxol treatment upregulates ST3Gal III expression and forces expression of ST3Gal III attenuated taxol induced apoptosis. Taxol induces the expression of ST3Gal III by a post-transcriptional mechanism in SKOV-3 ovarian cancer cells
up
General Information
General Information
Commentary
Organism
physiological function
ST3Gal III overexpression inhibits Taxol-triggered caspase-8 activation. ST3Gal III upregulation produces cellular resistance to taxol and hence reduces the efficacy of taxol therapy
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
ST3Gal III overexpression inhibits Taxol-triggered caspase-8 activation. ST3Gal III upregulation produces cellular resistance to taxol and hence reduces the efficacy of taxol therapy
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
taxol treatment upregulates ST3Gal III expression and forces expression of ST3Gal III attenuated taxol induced apoptosis. Taxol induces the expression of ST3Gal III by a post-transcriptional mechanism in SKOV-3 ovarian cancer cells
up
Other publictions for EC 2.4.99.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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723156
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723519
Perez-Garay
alpha2,3-Sialyltransferase ST3 ...
Homo sapiens
PLoS ONE
5
e12524
2010
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705677
Huang
Human beta-galactoside alpha-2 ...
Homo sapiens
Mol. Cell. Biochem.
331
81-88
2009
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1
1
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1
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1
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744308
Chandrasekaran
Reversible sialylation synthe ...
Rattus norvegicus
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320-330
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746526
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-
Chemoenzymatic synthesis of s ...
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alpha-(2->3)- and alpha-(2->6 ...
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