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Literature summary for 2.4.99.23 extracted from
- Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A (2018), Bioorg. Med. Chem. Lett., 28, 594-600 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| allyl-beta-D-galactopyranoside | 10% inhibition | Escherichia coli |  |
| allyl-beta-D-glucopyranoside | 19.6% inhibition | Escherichia coli | |
| D-galactose | 28.5% inhibition | Escherichia coli | |
| D-glucose | 36% inhibition | Escherichia coli | |
| decene-beta-D-galactopyranoside | 5% inhibition | Escherichia coli | |
| decene-beta-D-glucopyranoside | 23.4% inhibition | Escherichia coli | |
| heptene-beta-D-galactopyranoside | 7.8% inhibition | Escherichia coli | |
| heptene-beta-D-glucopyranoside | 11.9% inhibition | Escherichia coli | |
| hexene-beta-D-galactopyranoside | 22.6% inhibition | Escherichia coli | |
| hexene-beta-D-glucopyranoside | 29.7% inhibition | Escherichia coli | |
| methyl-alpha-D-galactopyranoside | 8.8% inhibition | Escherichia coli | |
| methyl-alpha-D-glucopyranoside | 27.8% inhibition | Escherichia coli | |
| methyl-beta-D-galactopyranoside | 7% inhibition | Escherichia coli | |
| methyl-beta-D-glucopyranoside | 19.5% inhibition | Escherichia coli | |
| n-octyl-beta-D-glucopyranoside | 8.3% inhibition | Escherichia coli | |
| octene-alpha-D-galactopyranoside | 8.8% inhibition | Escherichia coli | |
| octene-alpha-D-glucopyranoside | 16.7% inhibition | Escherichia coli | |
| octene-beta-D-galactopyranoside | 6.3% inhibition | Escherichia coli | |
| octene-beta-D-glucopyranoside | 4.2% inhibition | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli WBB06 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A] | - |
Escherichia coli | ADP + alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A] | - |
? | |
| ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A] | - |
Escherichia coli WBB06 | ADP + alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HepI | - |
Escherichia coli |
| heptosyltransferase I | - |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.28 | - |
D-glucose | pH and temperature not specified in the publication | Escherichia coli | |
| 0.34 | - |
hexene-beta-D-glucopyranoside | pH and temperature not specified in the publication | Escherichia coli | |
| 0.37 | - |
methyl-alpha-D-glucopyranoside | pH and temperature not specified in the publication | Escherichia coli | |
| 0.5 | - |
D-galactose | pH and temperature not specified in the publication | Escherichia coli | |
| 0.57 | - |
hexene-beta-D-galactopyranoside | pH and temperature not specified in the publication | Escherichia coli | |
| 0.65 | - |
allyl-beta-D-glucopyranoside | pH and temperature not specified in the publication | Escherichia coli | |
| 0.68 | - |
methyl-beta-D-glucopyranoside | pH and temperature not specified in the publication | Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | essential enzyme for the biosynthesis of the lipopolysaccharide | Escherichia coli |
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