Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.99.18 extracted from

  • Ramirez, A.S.; Kowal, J.; Locher, K.P.
    Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B (2019), Science, 366, 1372-1375 .
    View publication on PubMed
Search for more literature for 2.4.99.18

Application

Application Comment Organism
drug development cryoelectron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B provide a basis for the design of inhibitors of N-glycosylation that modulate the maturation and activation of protein markers involved in tumor formation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P46977 AND P0C6T2 AND P61165 AND P61803 AND P04843 AND P04844 AND P39656 AND Q9NRP0 oligosaccharyltransferase A complex (catalytic subunit). P46977: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A. P0C6T2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, P61165: transmembrane protein 258, P61803: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, P04843: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P04844: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P39656: dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit, Q9NRP0: oligosaccharyltransferase complex subunit OSTC
-
Homo sapiens Q8TCJ2 AND P0C6T2 AND P61165 AND P61803 AND P04843 AND P04844 AND P39656 AND Q9NRP0 oligosaccharyltransferase B complex. Q8TCJ2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B (catalytic subunit). P0C6T2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, P61165: transmembrane protein 258, P61803: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, P04843: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P04844: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P39656: dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit, Q9NRP0: oligosaccharyltransferase complex subunit OSTC
-

Synonyms

Synonyms Comment Organism
OST-A
-
 Homo sapiens
OST-B
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function oligosaccharyltransferase (OST) catalyzes the transfer of a high-mannose glycan onto secretory proteins in the endoplasmic reticulum. Mammals express two distinct oligosaccharyltransferase complexes that act in a cotranslational (OST-A) or posttranslocational (OST-B) manner. The distinct functions of the two human complexes are based on structural differences of their catalytic subunits STT3A and STT3B, which result in interactions with distinct subunits and different affinities for acceptor peptides Homo sapiens