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Literature summary for 2.4.99.18 extracted from

  • Izquierdo, L.; Schulz, B.L.; Rodrigues, J.A.; Guether, M.L.; Procter, J.B.; Barton, G.J.; Aebi, M.; Ferguson, M.A.
    Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases (2009), EMBO J., 28, 2650-2661.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.99.18

Application

Application Comment Organism
medicine enzyme inhibition could have therapeutic potential against trypanosomiasis Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
PCR-amplification, TbSTT3A expression in Saccharomyces cerevisiae does not replace yeast SST3 Trypanosoma brucei
PCR-amplification, TbSTT3B expression in Saccharomyces cerevisiae can replace yeast SST3, mild temperature-sensitive growth at 37°C, wild-type growth at 23°C Trypanosoma brucei
PCR-amplification, TbSTT3C expression in Saccharomyces cerevisiae can replace yeast SST3, severe growth defects at 23°C Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
RNAi silencing of TbSTT3A Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dolichyl diphosphooligosaccharide + protein L-asparagine Trypanosoma brucei
-
 dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information TbSTT3A transcribed in the bloodstream nor procyclic form Trypanosoma brucei
-
additional information TbSTT3B transcribed in the bloodstream nor procyclic form Trypanosoma brucei
-
additional information TbSTT3C not transcribed in the bloodstream nor procyclic form Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biantennary Man5GlcNAc2 dolichyl disphosphate + VSG221 coat glycoprotein selective transfer of TbSTT3A to acidic to neutral regions of polypeptides, responsible for all paucimannose and complex N-glycans in Trypanosoma brucei glycoproteins Trypanosoma brucei dolichyl disphosphate + ?
-
 ?
biantennary Man5GlcNAc2 dolichyl disphosphate + VSG221 coat glycoprotein selective transfer of TbSTT3A to acidic to neutral regions of polypeptides, responsible for all paucimannose and complex N-glycans in Trypanosoma brucei glycoproteins Trypanosoma brucei dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine
-
 ?
dolichyl diphosphooligosaccharide + protein L-asparagine
-
 Trypanosoma brucei dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine
-
 ?
triantennary Man9GlcNAc2 dolichyl disphosphate + VSG221 coat glycoprotein selective transfer of TbSTT3B to neutral to basic regions of polypeptides responsible for most or all oligomannose N-glycans in Trypanosoma brucei glycoproteins Trypanosoma brucei dolichyl disphosphate + protein with oligosaccharide attached to protein L-asparagine
-
 ?

Synonyms

Synonyms Comment Organism
oligosaccharyltransferase
-
 Trypanosoma brucei
OTase
-
 Trypanosoma brucei
TbSTT3A
-
 Trypanosoma brucei
TbSTT3B
-
 Trypanosoma brucei
TbSTT3C
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction simultaneous TbSTT3A and TbSTT3B knockdown prevents parasite growth in the bloodstream Trypanosoma brucei
physiological function TbSTT3A and TbSTT3B N-glycosylation together is essential for infectivity in mice Trypanosoma brucei