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Literature summary for 2.4.99.18 extracted from
- Studies on oligosaccharyl transferase in yeast (2007), Acta Biochim. Pol., 54, 673-677.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Ost4p is a minimembrane protein | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Ost5p is a membrane protein | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. Swp1p probably possesses three transmembrane segments, with its N-terminus in the lumen and C-terminus in the cytosol | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The functional domain of Ost1p is its membrane-anchored lumenal domain | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The Ost2 protein possesses three transmembrane segments, with its N-terminus in the cytosol and C-terminus directed towards the lumen | Saccharomyces cerevisiae | 16020 | - |
| membrane | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. The sequence of the lumen-oriented half of the transmembrane domain is important for the function of the Wbp1 protein | Saccharomyces cerevisiae | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | it may be that the lumenal domain of Ost1p is involved in funneling the newly synthesized polypeptides into the active site on Stt3p for the glycosylation oligosaccharyl transferase reaction | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P33767 | - |
- |
| Saccharomyces cerevisiae | P41543 | - |
- |
| Saccharomyces cerevisiae | P46964 | - |
- |
| Saccharomyces cerevisiae | P48439 | - |
- |
| Saccharomyces cerevisiae | Q02795 | - |
- |
| Saccharomyces cerevisiae | Q92316 | - |
- |
| Saccharomyces cerevisiae | Q99380 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | it may be that the lumenal domain of Ost1p is involved in funneling the newly synthesized polypeptides into the active site on Stt3p for the glycosylation oligosaccharyl transferase reaction | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p | Saccharomyces cerevisiae |
| More | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p. Four others are not essential Ost3p, Ost4p, Ost5p, Ost6p. Ost2p may aid Wbp1p in recognition of the Dol-PP-oligosaccharide | Saccharomyces cerevisiae |
| More | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p. Ost4p functions to bind Ost3p and Stt3p together in a subcomplex of oligosaccharyl transferase via interactions with its amino-acid residues near the cytosolic leaflet of the endoplasmic reticulum membrane. Ost4p is proposed to be responsible for recruiting Ost3p or Ost6p into the oligosaccharyl transferase complex | Saccharomyces cerevisiae |
| More | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p. Since the lumenal domain of Swp1p interacts with that of Ost1p, it may aid Ost1p in funneling nascent polypeptide chains into the active site of the oligosaccharyl transferase complex | Saccharomyces cerevisiae |
| More | oligosaccharyl transferase consists of nine different subunits, all of which contain one or more predicted transmembrane segments. In yeast, five of these proteins are encoded by essential genes, Swp1p, Wbp1p, Ost2p, Ost1p and Stt3p. Specific interaction between Ost3p and Sbh1p | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OST1 | - |
Saccharomyces cerevisiae |
| OST2 | - |
Saccharomyces cerevisiae |
| OST3 | - |
Saccharomyces cerevisiae |
| OST4 | - |
Saccharomyces cerevisiae |
| OST5 | - |
Saccharomyces cerevisiae |
| Swp1p | - |
Saccharomyces cerevisiae |
| Wbp1p | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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