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Literature summary for 2.4.99.12 extracted from
- Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli (2016), Proc. Natl. Acad. Sci. USA, 113, 3108-3113 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0AC75 | W3110 | - |
| Escherichia coli K12 | P0AC75 | W3110 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| WaaA | - |
Escherichia coli |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Escherichia coli | addition of palmitic acid to the growth medium of wild-type Escherichia coli elevates the levels of LpxC by 1.7-fold | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | a model for the biosynthesis of the outer membrane in Escherichia coli is presented. Lipopolysaccharide is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part regulated via degradation of LpxC and WaaA enzymes by the protease FtsH. Overexpression of waaA results in increased levels of 3-deoxy-D-manno-oct-2-ulosonic acid sugar in membrane extracts. Kdo and heptose levels are not elevated in lipopolysaccharides. This implies that uncontrolled production of WaaA does not increase the lipopolysaccharide production rate but rather reglycosylates lipid A precursors | Escherichia coli |
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Release 2023.1 (January 2023)
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