Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Mus musculus | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Homo sapiens | - |
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-F10 cell | - |
Mus musculus | - |
G-361 cell | - |
Homo sapiens | - |
melanoma cell | - |
Mus musculus | - |
melanoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Mus musculus | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? | |
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Homo sapiens | CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ganglioside GM3 synthase | - |
Mus musculus |
ganglioside GM3 synthase | - |
Homo sapiens |
GM3 synthase | - |
Mus musculus |
GM3 synthase | - |
Homo sapiens |
GM3S | - |
Mus musculus |
GM3S | - |
Homo sapiens |
ST3Gal5 | - |
Mus musculus |
ST3Gal5 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | chemical hypoxia treatment (0.1 mM CoCl2) decreases the expression of the enzyme | down |
Homo sapiens | chemical hypoxia treatment (0.1 mM CoCl2) decreases the expression of the enzyme | down |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency increases cellular resistance to oxidative stress (H2O2) and radiation therapy via upregulation of ERK | Mus musculus |
malfunction | enzyme deficiency increases cellular resistance to oxidative stress (H2O2) and radiation therapy via upregulation of ERK | Homo sapiens |
physiological function | the enzyme has an important role on cellular adaptive response to hypoxia | Mus musculus |
physiological function | the enzyme has an important role on cellular adaptive response to hypoxia | Homo sapiens |