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Literature summary for 2.4.3.9 extracted from

  • Shimizu, T.; Nagane, M.; Suzuki, M.; Yamauchi, A.; Kato, K.; Kawashima, N.; Nemoto, Y.; Maruo, T.; Kawakami, Y.; Yamashita, T.
    Tumor hypoxia regulates ganglioside GM3 synthase, which contributes to oxidative stress resistance in malignant melanoma (2020), Biochim. Biophys. Acta Gen. Subj., 1864, 129723 .
    View publication on PubMed
Search for more literature for 2.4.3.9

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Mus musculus
-
 CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F10 cell
-
 Mus musculus
-
G-361 cell
-
 Homo sapiens
-
melanoma cell
-
 Mus musculus
-
melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 Mus musculus CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Synonyms

Synonyms Comment Organism
ganglioside GM3 synthase
-
 Mus musculus
ganglioside GM3 synthase
-
 Homo sapiens
GM3 synthase
-
 Mus musculus
GM3 synthase
-
 Homo sapiens
GM3S
-
 Mus musculus
GM3S
-
 Homo sapiens
ST3Gal5
-
 Mus musculus
ST3Gal5
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus chemical hypoxia treatment (0.1 mM CoCl2) decreases the expression of the enzyme down
Homo sapiens chemical hypoxia treatment (0.1 mM CoCl2) decreases the expression of the enzyme down

General Information

General Information Comment Organism
malfunction enzyme deficiency increases cellular resistance to oxidative stress (H2O2) and radiation therapy via upregulation of ERK Mus musculus
malfunction enzyme deficiency increases cellular resistance to oxidative stress (H2O2) and radiation therapy via upregulation of ERK Homo sapiens
physiological function the enzyme has an important role on cellular adaptive response to hypoxia Mus musculus
physiological function the enzyme has an important role on cellular adaptive response to hypoxia Homo sapiens