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Literature summary for 2.4.3.9 extracted from

  • Sohn, H.; Kim, Y.; Kim, H.; Kim, C.; Cho, E.; Kang, H.; Kim, N.; Kim, C.; Ryu, S.E.; Lee, J.; Ko, J.H.
    Ganglioside GM3 is involved in neuronal cell death (2006), FASEB J., 20, 1248-1250.
    View publication on PubMed
Search for more literature for 2.4.3.9

Activating Compound

Activating Compound Comment Organism Structure
additional information GM3 is up-regulated in glutamate-induced neuronal cell death Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
functional expression in HT22 cells, GM3 levels are increased in immortalized mouse hippocampal HT22 cells after exposure to glutamate, GM3 not only mediates the effect of glutamate on the oxidative death of HT22 cells but also acts, in itself, as a modulator of in vivo neuronal cell death, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + lactosylceramide Mus musculus ganglioside GM3 is involved in neuronal cell death CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O88829
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + lactosylceramide
-
 Mus musculus CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?
CMP-N-acetylneuraminate + lactosylceramide ganglioside GM3 is involved in neuronal cell death Mus musculus CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?

Synonyms

Synonyms Comment Organism
GM3 synthase
-
 Mus musculus
ST3GalV
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 Mus musculus