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Literature summary for 2.4.3.9 extracted from
- Inhibition of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase by nucleotides, nucleotide sugars and nucleotide dialdehydes (1993), Biochem. Biophys. Res. Commun., 193, 585-590.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CMP | - |
Gallus gallus |  |
| CMPdialdehyde | kinetics | Gallus gallus | |
| UDP | - |
Gallus gallus | |
| UDP-N-acetylgalactosamine | weak | Gallus gallus | |
| UDPdialdehyde | kinetics | Gallus gallus | |
| UDPgalactose | weak | Gallus gallus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0815 | - |
lactosylceramide | - |
Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Gallus gallus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CMP-N-acetylneuraminate + lactosylceramide | Gallus gallus | synthesizes the first ganglioside of the gangliotetraose series, GM3 | CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
15 days old embryo | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide | - |
Gallus gallus | CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide | i.e. ganglioside GM3 | ? | |
| CMP-N-acetylneuraminate + lactosylceramide | synthesizes the first ganglioside of the gangliotetraose series, GM3 | Gallus gallus | CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0853 | - |
CMP-dialdehyde | at 0.1 mM | Gallus gallus | |
| 0.104 | - |
CMP-dialdehyde | at 0.2 mM | Gallus gallus | |
| 0.219 | - |
UDP-dialdehyde | at 0.2 mM | Gallus gallus | |
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