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Literature summary for 2.4.3.9 extracted from

  • Busam, K.; Decker, K.
    Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases (1986), Eur. J. Biochem., 160, 23-30.
    View publication on PubMed
Search for more literature for 2.4.3.9

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 activation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ba2+ weak Rattus norvegicus
Ca2+ weak Rattus norvegicus
Cd2+ strong Rattus norvegicus
Co2+
-
 Rattus norvegicus
Cu2+ strong Rattus norvegicus
Mn2+ weak Rattus norvegicus
additional information not inhibited by EDTA; not inhibited by Fe2+, Mg2+, IAA, 2-mercaptoethanol Rattus norvegicus
Ni2+ strong Rattus norvegicus
Zn2+ weak Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
 lactosylceramide
-
 Rattus norvegicus
1.5
-
 CMP-N-acetyl-beta-neuraminate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no metal ion requirement Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Wistar
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Rattus norvegicus CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. ganglioside GM3 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.7
-
-
 Rattus norvegicus