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Literature summary for 2.4.3.8 extracted from

  • Nakayama, J.; Fukuda, M.; Hirabayashi, Y.; Kanamori, A.; Sasaki, K.; Nishi, T.; Fukuda, M.
    Expression cloning of a human GT3 synthase GD3 and GT3 are synthesized by a single enzyme (1996), J. Biol. Chem., 271, 3684-3691 .
    View publication on PubMed
Search for more literature for 2.4.3.8

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 20 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + ganglioside GD3 Homo sapiens NeuNAcalpha(2->8)NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer ganglioside GT3 + CMP + H+
-
 ?
CMP-N-acetylneuraminate + ganglioside GM3 Homo sapiens NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer ganglioside GD3 + CMP + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92185
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the enzyme expression is highly restricted to fetal and adult brains Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MeWo cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + ganglioside GD3 NeuNAcalpha(2->8)NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer Homo sapiens ganglioside GT3 + CMP + H+
-
 ?
CMP-N-acetylneuraminate + ganglioside GM3 NeuNAcalpha(2->3)Galbeta(1->4)Glc->Cer Homo sapiens ganglioside GD3 + CMP + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 40517, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
EC 2.4.99.8 formerly Homo sapiens
GD3/GT3 synthase
-
 Homo sapiens
GD3/GT3ST
-
 Homo sapiens
GT3 synthase
-
 Homo sapiens
STII
-
 Homo sapiens
STIII
-
 Homo sapiens