Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.3.8 extracted from

  • Yamashiro, S.; Okada, M.; Haraguchi, M.; Furukawa, K.; Lloyd, K.; Shiku, H.; Furukawa, K.
    Expression of alpha2,8-sialyltransferase (GD3 synthase) gene in human cancer cell lines high level expression in melanomas and up-regulation in activated T lymphocytes (1995), Glycoconj. J., 12, 894-900 .
    View publication on PubMed
Search for more literature for 2.4.3.8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + a ganglioside GM3 Homo sapiens
-
 a ganglioside GD3 + CMP + H+
-
 ?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Ara-10 cell
-
 Homo sapiens
-
astrocytoma cell
-
 Homo sapiens
-
ATN-1 cell
-
 Homo sapiens
-
Burkitt lymphoma cell
-
 Homo sapiens
-
CCRF-CEM cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
HUT-102 cell
-
 Homo sapiens
-
IMR-32 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
leukemia cell
-
 Homo sapiens
-
MEG-01 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
MeWo cell
-
 Homo sapiens
-
MOLT-3 cell
-
 Homo sapiens
-
MT-2 cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
P12-ICHIKAWA cell
-
 Homo sapiens
-
RAJI cell
-
 Homo sapiens
-
SK-MEL-23 cell
-
 Homo sapiens
-
SK-MEL-31 cell
-
 Homo sapiens
-
SK-MEL-37 cell
-
 Homo sapiens
-
SK-MEL-38 cell
-
 Homo sapiens
-
SK-N-SH cell
-
 Homo sapiens
-
T-cell acute lymphoblastic leukemia cell
-
 Homo sapiens
-
YTN-17 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + a ganglioside GM3
-
 Homo sapiens a ganglioside GD3 + CMP + H+
-
 ?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?

Synonyms

Synonyms Comment Organism
alpha2,8-sialyltransferase
-
 Homo sapiens
alpha2,8S-T
-
 Homo sapiens
GD3 synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme expression is high in melanoma and upregulated in activated T-lymphocytes up