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Literature summary for 2.4.3.8 extracted from

  • Lin, C.; Lai, H.; Chen, H.; Siew, J.; Hsiao, C.; Chang, H.; Liao, K.; Tsai, S.; Wu, C.; Kitajima, K.; Sato, C.; Khoo, K.; Chern, Y.
    Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors (2019), Transl. Psychiatry, 9, 209 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.8

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R Mus musculus
-
 CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64689
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
cerebellum
-
 Mus musculus
-
cerebral cortex
-
 Mus musculus
-
corpus striatum highest expression Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + adenosine A2A receptor
-
 Mus musculus CMP + ?
-
 ?
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 Mus musculus CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?
CMP-N-acetylneuraminate + dopamine D1 receptor
-
 Mus musculus CMP + ?
-
 ?
CMP-N-acetylneuraminate + dopamine D2 receptor
-
 Mus musculus CMP + ?
-
 ?
CMP-N-acetylneuraminate + type V adenylyl cyclase
-
 Mus musculus CMP + ?
-
 ?
additional information the glutamate receptors NR1, NR2A, NR2B, GluR1, and GluR2 are no substrates Mus musculus ?
-
-

Subunits

Subunits Comment Organism
? x * about 40000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ST8 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
-
 Mus musculus
ST8SIA3
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the lack of enzyme-mediated sialylation of adenosine A2A receptor and dopamine D2 receptor alters the distribution of these proteins in lipid rafts and the interaction between them. Enzyme depletion reduces the number of disialyl and trisialyl units on striatal N- and O-glycans Mus musculus