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Literature summary for 2.4.3.8 extracted from

  • Zhang, X.; Dong, W.; Zhou, H.; Li, H.; Wang, N.; Miao, X.; Jia, L.
    alpha-2,8-Sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt pathway in human chronic myeloid leukemia (2015), IUBMB Life, 67, 77-87.
    View publication on PubMed
Search for more literature for 2.4.3.8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chronic myeloid leukemia cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
K-562/ADR cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
-
 ?

Synonyms

Synonyms Comment Organism
alpha-2,8-sialyltransferase
-
 Homo sapiens
ST8SIA4 isoform Homo sapiens

General Information

General Information Comment Organism
malfunction silencing of the ST8SIA4 gene enhances chemosensitivity of K562/ADR cells in vitro and in vivo Homo sapiens
metabolism isoform ST8SIA4 mediates the activity of phosphoinositide-3 kinase/Akt signaling pathway and the expression of P-glycoprotein Homo sapiens
physiological function the enzyme is involved in the development of multidrug resistance via phosphoinositide-3 kinase/Akt pathway in human chronic myeloid leukemia Homo sapiens