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Literature summary for 2.4.3.8 extracted from

  • Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.
    Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver (1987), Biol. Chem. Hoppe-Seyler, 368, 455-462.
    View publication on PubMed
Search for more literature for 2.4.3.8

Activating Compound

Activating Compound Comment Organism Structure
additional information the presence of detergents is essential for activity, no activation by phosphatidylglycerol Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ganglioside D1a
-
 Rattus norvegicus
Ganglioside Q1b strong Rattus norvegicus
Ganglioside T1b
-
 Rattus norvegicus
additional information no inhibition by ganglioside GM2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-
membrane
-
 Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. disialosyllactosylceramide or ganglioside GD3 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus