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Literature summary for 2.4.3.7 extracted from

  • Harduin-Lepers, A.; Stokes, D.C.; Steelant, W.F.A.; Samyn-Petit, B.; Krzewinski-Recchi, M.A.; Vallejo-Ruiz, V.; Zanetta, J.P.; Auge, C.; Delannoy, P.
    Cloning, expression and gene organization of a human Neu5Aca2-3Galb1-3GalNAc a2,6-sialyltransferase: hST6GalNAc IV (2000), Biochem. J., 352, 37-48.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.7

Cloned(Commentary)

Cloned (Comment) Organism
expression of ST6GalNac IV in COS-7 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 CMP-N-acetylneuraminate
-
 Homo sapiens
1.1
-
 Neu5Acalpha2-3Galbeta1-3GalNac
-
 Homo sapiens
2.21
-
 Neu5Acalpha2-3Galbeta1-3GalNacalpha-O-benzyl
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34900
-
 x * 34900, deduced from nucleotide sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H4F1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain constitutive expression of ST6GalNac IV gene Homo sapiens
-
colon constitutive expression of ST6GalNac IV gene Homo sapiens
-
heart constitutive expression of STGalNac IV gene Homo sapiens
-
kidney constitutive expression of ST6GalNac IV gene Homo sapiens
-
liver constitutive expression of ST6GalNac IV gene Homo sapiens
-
lung constitutive expression of ST6GalNac IV gene Homo sapiens
-
placenta constitutive expression of ST6GalNac IV gene Homo sapiens
-
skeletal muscle constitutive expression of ST6GalNac IV gene Homo sapiens
-
small intestine constitutive expression of ST6GalNac IV gene Homo sapiens
-
spleen constitutive expression of ST6GalNac IV gene Homo sapiens
-
thymus constitutive expression of ST6GalNac IV gene Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + Neu5Acalpha2-3Galbeta1-3GalNacalpha-O-benzyl
-
 Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + alpha1-acid glycoprotein acceptor structur: Neu5Acalpha2-6Galbeta1-4GlcNac-R, 8.7% of activity with fetuin Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + fetuin acceptor structures: Neu5Acalpha2-3Galbeta1-3GalNacalpha1-O-Ser/Thr, Neu5Acalpha2-3Galbeta1-3[Neu5Acalpha2-6]GalNacalpha1-O-Ser/Thr and Neu5Acalpha2-6(3)Galbeta1-4GlcNac-R Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + GlcNac-alpha1-O-benzyl 7.6% of activity with fetuin Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + Neu5Acalpha2-3Galbeta1-3GalNac 60.3% of activity with fetuin Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + Neu5Acalpha2-3Galbeta1-4GlcNac-alpha1-O-benzyl 224% of activity with fetuin Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 34900, deduced from nucleotide sequence Homo sapiens