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Literature summary for 2.4.3.6 extracted from

  • Kono, M.; Ohyama, Y.; Lee, Y.C.; Hamamoto, T.; Kojima, N.; Tsuji, S.
    Mouse beta-galactoside alpha2,3-sialyltransferases comparison of in vitro substrate specificities and tissue specific expression (1997), Glycobiology, 7, 469-479 .
    View publication on PubMed
Search for more literature for 2.4.3.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells as a recombinant enzyme fused with protein A Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
 beta-D-Gal-(1->4)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
0.75
-
 beta-D-Gal-(1->3)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
3
-
 beta-D-Gal-(1->4)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P97325
-
-
Mus musculus Q91Y74
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
colon
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
spleen
-
 Mus musculus
-
testis weak expression Mus musculus
-
thymus
-
 Mus musculus
-
thymus weak expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GlcNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc
-
 ?
CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->4)-beta-D-GlcNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc
-
 ?
CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->4)-beta-D-GlcNAc relative Vmax for ST3Gal III is 4:2:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc as substrate, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc
-
 ?

Synonyms

Synonyms Comment Organism
ST3Gal III
-
 Mus musculus
ST3Gal IV
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
-
 Mus musculus