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Literature summary for 2.4.3.4 extracted from

  • Guerrero, P.; Miro, L.; Wong, B.; Massaguer, A.; Martinez-Bosch, N.; de Llorens, R.; Navarro, P.; Konstantopoulos, K.; Llop, E.; Peracaula, R.
    Knockdown of alpha2,3-sialyltransferases impairs pancreatic cancer cell migration, invasion and E-selectin-dependent adhesion (2020), Int. J. Mol. Sci., 21, 1-24 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + a type 3 histo-blood group antigen precursor disaccharide Homo sapiens
-
 an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R + CMP + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
-
 Homo sapiens
-
BxPC-3 cell
-
 Homo sapiens
-
CAPAN-1 cell
-
 Homo sapiens
-
CAPAN-2 cell
-
 Homo sapiens
-
HPAF-2 cell
-
 Homo sapiens
-
Panc 10.05 cell
-
 Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-
SW-1990 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + a type 3 histo-blood group antigen precursor disaccharide
-
 Homo sapiens an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R + CMP + H+
-
 ?

Synonyms

Synonyms Comment Organism
beta-galactoside alpha2,3-sialyltransferase
-
 Homo sapiens
ST3Gal3
-
 Homo sapiens
ST3GAL4
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction downregulation of isoforms ST3GAL3 and ST3GAL4 results in a significant decrease in cell migration and invasion as well as E-selectin-dependent adhesion of pancreatic cancer cells. Downregulation of isoforms ST3GAL4 and ST3GAL3 in BxPC-3 and Capan-1 cells reduces sLex expression Homo sapiens