Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.3.3 extracted from

  • Marcos, N.T.; Pinho, S.; Grandela, C.; Cruz, A.; Samyn-Petit, B.; Harduin-Lepers, A.; Almeida, R.; Silva, F.; Morais, V.; Costa, J.; Kihlberg, J.; Clausen, H.; Reis, C.A.
    Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen (2004), Cancer Res., 64, 7050-7057.
    View publication on PubMed
Search for more literature for 2.4.3.3

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
 x * 65000, isoform ST6GalNAc-I, x * 39000, isoform ST6GalNAc-II, SDS-PAGE Homo sapiens
65000
-
 x * 65000, isoform ST6GalNAc-I, x * 39000, isoform ST6GalNAc-II, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms ST6GalNAc-I and ST6GalNAc-II, recombinant enzymes
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information no proteolytic cleavage at N-terminus of both isoform ST6GalNAc-I and ST6GalNAc-II Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-Neu5Ac + asialofetuin
-
 Homo sapiens CMP + ?
-
 ?
CMP-Neu5Ac + fetuin isoform ST6GalNAc-I, 84% of reactivity with asialofetuin, isoform ST6GalNAc-II, 88% of reactivity with asialofetuin Homo sapiens CMP + ?
-
 ?
CMP-Neu5Ac + HIV 120gp (17-mer) isoform ST6GalNAc-I, 34% of reactivity with asialofetuin, isoform ST6GalNAc-II, 38% of reactivity with asialofetuin Homo sapiens CMP + ?
-
 ?
CMP-Neu5Ac + HIV 120gp (21-mer) isoform ST6GalNAc-I, 62% of reactivity with asialofetuin, isoform ST6GalNAc-II, 58% of reactivity with asialofetuin Homo sapiens CMP + ?
-
 ?
additional information enzyme transfers sialic acid to O-linked oligosaccharide of glycoprotein, isoform ST6GalNAc-I prefers sialyl Tn antigen, i.e. Neu5Acalpha2-6GalNAc-O-Ser/Thr, isoform ST6GalNAc-II prefers T antigen as substrate Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 65000, isoform ST6GalNAc-I, x * 39000, isoform ST6GalNAc-II, SDS-PAGE Homo sapiens