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Literature summary for 2.4.3.2 extracted from

  • Kojima, N.; Lee, Y.C.; Hamamoto, T.; Kurosawa, N.; Tsuji, S.
    Kinetic properties and acceptor substrate preferences of two kinds of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain (1994), Biochemistry, 33, 5772-5776 .
    View publication on PubMed
Search for more literature for 2.4.3.2

Inhibitors

Inhibitors Comment Organism Structure
beta-D-Gal-(1->3)-beta-D-GalNAc the enzyme exhibits competitive inhibition between all kinds of acceptors; the enzyme exhibits noncompetitive inhibition between ganglioside GA1 and beta-D-Gal-(1->3)-beta-D-GalNAc or between ganglioside GA1 and [asialofeuin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine Mus musculus
ganglioside GA1 the enzyme exhibits competitive inhibition between all kinds of acceptors; the enzyme exhibits noncompetitive inhibition between ganglioside GA1 and beta-D-Gal-(1->3)-beta-D-GalNAc or between ganglioside GA1 and [asialofeuin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 ganglioside GA1 pH and temperature not specified in the publication Mus musculus
1.25
-
 ganglioside GA1 pH and temperature not specified in the publication Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P54751
-
-
Mus musculus Q11204
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc
-
 Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
 ?
CMP-N-acetyl-beta-neuraminate + ganglioside GA1
-
 Mus musculus CMP + ganglioside GM1b
-
 ?
additional information acceptor preference of ST3GalA.1 is different from that of ST3GalA.2, although their acceptor substrate specificities are the same; i.e., gangliosides serve as predominant acceptors for the latter over O-glycosidically linked oligosaccharides of glycoproteins, which are much better acceptors for the former Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ST3GalA.1
-
 Mus musculus
ST3GalA.2
-
 Mus musculus