Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64685 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ST6Gal1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | B cells of mice lacking the hepatocyte specific enzyme promoter have reduced sialylation of cell surface CD22 and CD45 and produce less immunoglobulin G upon stimulation | Mus musculus |
physiological function | the enzyme is essential to the development of a robust and tolerant humoral immunity. Extracellular enzyme enhances B cell IgG production and increases blood IgG titers. Sialylation of B cells by extracellular enzyme boosts expression of immunoglobulin M, immunoglobulin D, and CD86, proliferation, and immunoglobulin G production in vitro. In vivo, elevation of blood enzyme enhances B cell development and systemic IgG in a CD22-dependent manner | Mus musculus |