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Literature summary for 2.4.3.1 extracted from

  • Irons, E.E.; Punch, P.R.; Lau, J.T.Y.
    Blood-borne ST6GAL1 regulates immunoglobulin production in B cells (2020), Front. Immunol., 11, 617 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q64685
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Mus musculus
-
liver
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
ST6Gal1
-
Mus musculus

General Information

General Information Comment Organism
malfunction B cells of mice lacking the hepatocyte specific enzyme promoter have reduced sialylation of cell surface CD22 and CD45 and produce less immunoglobulin G upon stimulation Mus musculus
physiological function the enzyme is essential to the development of a robust and tolerant humoral immunity. Extracellular enzyme enhances B cell IgG production and increases blood IgG titers. Sialylation of B cells by extracellular enzyme boosts expression of immunoglobulin M, immunoglobulin D, and CD86, proliferation, and immunoglobulin G production in vitro. In vivo, elevation of blood enzyme enhances B cell development and systemic IgG in a CD22-dependent manner Mus musculus