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Literature summary for 2.4.3.1 extracted from

  • Ribitsch, D.; Zitzenbacher, S.; Augustin, P.; Schmoelzer, K.; Czabany, T.; Luley-Goedl, C.; Thomann, M.; Jung, C.; Sobek, H.; Mueller, R.; Nidetzky, B.; Schwab, H.
    High-quality production of human alpha-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities (2014), Microb. Cell Fact., 13, 138.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris strain KM71H Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the truncated enzyme DELTA108 is active as alpha2,6-sialyltransferase and CMP-N-acetylneuraminate hydrolase Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + asialofetuin
-
 Homo sapiens ?
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
CMP-N-acetylneuraminate + lactosamine
-
 Homo sapiens ?
-
 ?
additional information no activity with 6'-sialyllactosamine Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
alpha-2,6-sialyltransferase
-
 Homo sapiens
ST6Gal-I
-
 Homo sapiens