Literature summary for 2.4.3.1 extracted from

Nycholat, C.M.; Peng, W.; McBride, R.; Antonopoulos, A.; de Vries, R.P.; Polonskaya, Z.; Finn, M.G.; Dell, A.; Haslam, S.M.; Paulson, J.C.
Synthesis of biologically active N- and O-linked glycans with multisialylated poly-N-acetyllactosamine extensions using P. damsela alpha2-6 sialyltransferase (2013), J. Am. Chem. Soc., 135, 18280-18283.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine	Photobacterium damselae	-	CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Photobacterium damselae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine	-	Photobacterium damselae	CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine	-	?
additional information	the enzyme exhibits a unique regioselectivity and is able to sialylate internal galactose residues in poly-LacNAc extended glycans	Photobacterium damselae	?	-	?

Synonyms

Synonyms	Comment	Organism
2,6ST	-	Photobacterium damselae
alpha2-6 sialyltransferase	-	Photobacterium damselae

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Release 2023.1 (January 2023)