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Literature summary for 2.4.3.1 extracted from

  • Kitazume, S.; Oka, R.; Ogawa, K.; Futakawa, S.; Hagiwara, Y.; Takikawa, H.; Kato, M.; Kasahara, A.; Miyoshi, E.; Taniguchi, N.; Hashimoto, Y.
    Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo (2009), Glycobiology, 19, 479-487.
    View publication on PubMed
Search for more literature for 2.4.3.1

Cloned(Commentary)

Cloned (Comment) Organism
Hep3B cells stably expressing human BACE1-myc or ST6Gal I Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi complex exogenous and endogenous ST6Gal I in the perinuclear Golgi of Hep3B-ST6Gal I and control Hep3B cells Homo sapiens
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additional information oxidative stress changes the intracellular localizations of ST6Gal I and BACE1, more disperse localizations Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens P15907
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Rattus norvegicus P13721 male Sprague-Dawley and Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Rattus norvegicus
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blood serum level of serum ST6Gal I in patients with chronic active hepatitis is significantly increased compared to that in patients with chronic persistent hepatitis. Serum level of ST6Gal I in hepatitis C patients is correlated with the activity of hepatic inflammation, but not with liver fibrosis Homo sapiens
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Synonyms

Synonyms Comment Organism
beta-galactoside alpha2,6-sialyltransferase
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 Rattus norvegicus
beta-galactoside alpha2,6-sialyltransferase
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 Homo sapiens
ST6Gal I
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 Rattus norvegicus
ST6Gal I
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 Homo sapiens

Expression

Organism Comment Expression
Rattus norvegicus level of plasma ST6Gal I is increased in two different types of liver injury models: in zone 1 hepatocyte-injured rats, the level of plasma ST6Gal I is increased together with acute phase reactions. Meanwhile, in zone 3 hepatocyte-injured rats, ST6Gal I secretion is most likely triggered by oxidative stress up