Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.3.1 extracted from

  • Liu, S.; Venot, A.; Meng, L.; Tian, F.; Moremen, K.W.; Boons, G.; Prestegard, J.H.
    Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha -2,6-sialyltransferase ST6Gal I (2007), Chem. Biol., 14, 409-418.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.3.1

Inhibitors

Inhibitors Comment Organism Structure
CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl]
-
 Rattus norvegicus
CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl]
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P13721
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + N-acetyllactosamine
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-2,6-sialyltransferase
-
 Rattus norvegicus
ST6Gal I
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.79
-
 CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl] pH 6.5, 37°C Rattus norvegicus
4.07
-
 CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl] pH 6.5, 37°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.7
-
 pH 6.5, 37°C Rattus norvegicus CMP-4-O-[4-carboxy-2,2,6,6-tetramethylpiperidinine-1-oxyl]
8.7
-
 pH 6.5, 37°C Rattus norvegicus CMP-4-O-[2,2,6,6-tetramethylpiperidine-1-oxyl]