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Literature summary for 2.4.3.1 extracted from

  • Chen, T.L.; Chen, C.; Bergeron, N.Q.; Close, B.E.; Bohrer, T.J.; Vertel, B.M.; Colley, K.J.
    The two rat alpha 2,6-sialyltransferase (ST6Gal I) isoforms: evaluation of catalytic activity and intra-Golgi localization (2003), Glycobiology, 13, 109-117.
    View publication on PubMed
Search for more literature for 2.4.3.1

Cloned(Commentary)

Cloned (Comment) Organism
isoform STcys expressed in CHO cells or in HeLa cells Rattus norvegicus
isoform STtyr expressed in CHO cells or in HeLa cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.147
-
 asialo-alpha1-acid glycoprotein
-
 Rattus norvegicus
0.163
-
 asialo-alpha1-acid glycoprotein
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-
endoplasmic reticulum isoform Stcys is found in both the endoplasmic reticulum and in Golgi Rattus norvegicus 5783
-
Golgi vesicle in medial-trans regions. Isoform Stcys is found in both the endoplasmic reticulum and in Golgi Rattus norvegicus
-
-
Golgi vesicle in medial-trans regions. Isoform STtyr is restricted to Golgi in most cells Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme functions in Golgi vesicles to terminally sialylate the N-linked oligosaccharides of glycoproteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 isoform STcys
-
Rattus norvegicus
-
 isoform STtyr
-

Purification (Commentary)

Purification (Comment) Organism
isoform STcys Rattus norvegicus
isoform STtyr Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-9-O-acetyl-N-acetylneuraminate + asialo-alpha1-acid glycoprotein
-
 Rattus norvegicus CMP + ?
-
 ?
CMP-N-acetylneuraminate + asialo-fetuin recombinant isoform STcys is somewhat more active then the recombinant isoform STtyr Rattus norvegicus CMP + fetuin
-
 ?
CMP-N-acetylneuraminate + asialo-transferrin
-
 Rattus norvegicus CMP + transferrin
-
 ?
additional information the enzyme functions in Golgi vesicles to terminally sialylate the N-linked oligosaccharides of glycoproteins Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha 2,6-sialyltransferase
-
 Rattus norvegicus
ST6Gal I
-
 Rattus norvegicus