Inhibitors | Comment | Organism | Structure |
---|---|---|---|
endo F | inactivation due to deglycosylation of the enzyme, best in methanol or ethanol, less efficient than glycanase | Rattus norvegicus | |
glycanase | inactivation due to deglycosylation of the enzyme, best in methanol or ethanol | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | membrane-bound at the luminal side, trans compartment | Rattus norvegicus | 5794 | - |
Golgi trans face | - |
Rattus norvegicus | - |
- |
membrane | - |
Rattus norvegicus | 16020 | - |
additional information | enzyme is not catalytically active in the endoplasmic reticulum and only achieves full activity when it locates itself to the trans compartment of the Golgi system | Rattus norvegicus | - |
- |
Organic Solvent | Comment | Organism |
---|---|---|
Methanol | stable at 10%, 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
purified enzyme | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | contains at least 2 N-linked carbohydate chains of the complex type | Rattus norvegicus |
glycoprotein | catalytic activity of the enzyme depends on the presence of oligosaccharide chains | Rattus norvegicus |
additional information | deglycosylation of the enzyme is much more efficient in presence of methanol or ethanol | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R | sialic acid is linked to C-6 of the galactose residue | Rattus norvegicus | CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Galbeta1,4-GlcNAc alpha2,6 sialyltransferase | - |
Rattus norvegicus |