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Literature summary for 2.4.3.1 extracted from

  • Fast, D.G.; Jamieson, J.C.; McCaffrey, G.
    The role of the carbohydrate chains of Gal beta-1,4-GlcNAc alpha 2,6-sialyltransferase for enzyme activity (1993), Biochim. Biophys. Acta, 1202, 325-330.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
endo F inactivation due to deglycosylation of the enzyme, best in methanol or ethanol, less efficient than glycanase Rattus norvegicus
glycanase inactivation due to deglycosylation of the enzyme, best in methanol or ethanol Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus membrane-bound at the luminal side, trans compartment Rattus norvegicus 5794
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Golgi trans face
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Rattus norvegicus
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membrane
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Rattus norvegicus 16020
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additional information enzyme is not catalytically active in the endoplasmic reticulum and only achieves full activity when it locates itself to the trans compartment of the Golgi system Rattus norvegicus
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Organic Solvent Stability

Organic Solvent Comment Organism
Methanol stable at 10%, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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purified enzyme
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein contains at least 2 N-linked carbohydate chains of the complex type Rattus norvegicus
glycoprotein catalytic activity of the enzyme depends on the presence of oligosaccharide chains Rattus norvegicus
additional information deglycosylation of the enzyme is much more efficient in presence of methanol or ethanol Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
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?

Synonyms

Synonyms Comment Organism
Galbeta1,4-GlcNAc alpha2,6 sialyltransferase
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Rattus norvegicus