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Literature summary for 2.4.3.1 extracted from

  • Paulson, J.C.; Rearick, J.I.; Hill, R.L.
    Enzymatic properties of beta-D-galactoside alpha2 leads to 6 sialytransferase from bovine colostrum (1977), J. Biol. Chem., 252, 2363-2371.
    View publication on PubMed
Search for more literature for 2.4.3.1

Inhibitors

Inhibitors Comment Organism Structure
N-acetyllactosamine with asialo-alpha1 acid glycoprotein as substrate Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic mechanism Bos taurus
12
-
 N-acetyllactosamine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
colostrum
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + asialo-fetuin
-
 Bos taurus CMP + fetuin
-
 ?
CMP-N-acetylneuraminate + asialo-immunoglobulin G
-
 Bos taurus CMP + immunoglobulin G
-
 ?
CMP-N-acetylneuraminate + asialo-immunoglobulin M
-
 Bos taurus CMP + immunoglobulin M
-
 ?
CMP-N-acetylneuraminate + asialo-orosomucoid best substrate Bos taurus CMP + orosomucoid
-
 ?
CMP-N-acetylneuraminate + asialo-orosomucoid i.e. asialo-alpha1 acid glycoprotein Bos taurus CMP + orosomucoid
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine best substrate Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine i.e. N-acetyllactosamine Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R acceptor substrate specificity Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R R: glycoprotein or glycopeptide Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R strictly specific for CMP-N-acetylneuraminate, forms only alpha2,6-linkages Bos taurus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?
CMP-N-acetylneuraminate + fetuin
-
 Bos taurus ?
-
 ?
CMP-N-acetylneuraminate + lactose poor substrate Bos taurus CMP + 6'-sialyllactose
-
 ?
additional information no activity with beta-methyl-L-arabinopyranoside Bos taurus ?
-
 ?
additional information no activity with antifreeze glycoprotein Bos taurus ?
-
 ?
additional information poor substrates are the beta-1,3- or beta-1,6-derivatives of beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine Bos taurus ?
-
 ?
additional information no activity with ovine submaxillary asialo-mucin Bos taurus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus