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Literature summary for 2.4.2.9 extracted from

  • Natalini, P.; Ruggieri, S.; Santarelli, I.; Vita, A.; Magni, G.
    Bakers yeast UMP:pyrophosphate phosphoribosyltransferase. Purification, enzymatic and kinetic properties (1979), J. Biol. Chem., 254, 1558-1563.
    View publication on PubMed

General Stability

General Stability Organism
enzyme is highly unstable, dimethyl sulfoxide stabilizes during purification Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
dCMP allosteric inhibition Saccharomyces cerevisiae
dCTP allosteric inhibition Saccharomyces cerevisiae
dUMP allosteric inhibition Saccharomyces cerevisiae
TTP allosteric inhibition Saccharomyces cerevisiae
UDP allosteric inhibition Saccharomyces cerevisiae
UMP allosteric inhibition Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.021
-
Uracil
-
Saccharomyces cerevisiae
0.026
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
gel filtration Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae UMP + diphosphate
-
?

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
22 42
-
Saccharomyces cerevisiae

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
2 min, complete loss of activity, 1 mM uracil + 0.1 EDTA protect partially Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6 7.8
-
Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
6.5 10
-
Saccharomyces cerevisiae