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Literature summary for 2.4.2.8 extracted from

  • Townsend, M.H.; Felsted, A.M.; Burrup, W.; Robison, R.A.; O'Neill, K.L.
    Examination of hypoxanthine guanine phosphoribosyltransferase as a biomarker for colorectal cancer patients (2018), Mol. Cell. Oncol., 5, e1481810 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.8

Application

Application Comment Organism
diagnostics there is other evidence of salvage enzymes serving as diagnostic and prognostic biomarkers to diagnose and monitor cancer development in patient. Evaluation of enzymes, including HPRT, APRT, and DCK, as potential biomarkers for colorectal cancer (CRC). Colorectal cancer cell lines SW-480, SW-620, and HT-29 have statistically significant HPRT expression on the surface of the cells, while Colo-205 cells show no significant increase in the surface presence of HPRT. Analysis within malignant colon samples confirms the variable nature of HPRT surface localization within patients Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
additional information analysis within malignant colon samples confirms the variable nature of HPRT surface localization within patients Homo sapiens
-
-
plasma membrane HPRT is strongly associated with the plasma membrane of SW-620 cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 GMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 IMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00492
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Colo-205 cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
SW-620 cell HPRT is strongly associated with the plasma membrane of SW-620 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens GMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens IMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
HPRT
-
 Homo sapiens
hypoxanthine guanine phosphoribosyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function having functional salvage pathway enzymes is important in the survival and functionality of mammalian cells. Salvage enzymes, such as HPRT, are known as common housekeeping genes, and are integral in several daily cellular functions regulating cell proliferation and cell cycle progression Homo sapiens