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Literature summary for 2.4.2.8 extracted from
- Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: Preliminary data of an ongoing series (2011), Nucleosides Nucleotides Nucleic Acids, 30, 1085-1090.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | prospective pharmacodynamic study to determine the effect of combination therapy for treatment of inflammatory bowel disease on the activity of hypoxanthine-guanine phosphoribosyltransferase, which activates of thiopurine prodrugs to thioguanine nucleotides. The activity of hypoxanthine-guanine phosphoribosyltransferase and thioguanine nucleotides concentrations was measured in red blood cells during thiopurine monotherapy and after 4 weeks of combination therapy. The activity of hypoxanthine-guanine phosphoribosyltransferase was also measured after 12 weeks of combination therapy. Combination therapy increases the activity of hypoxanthine-guanine phosphoribosyltransferase and subsequently thioguanine nucleotides concentrations | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
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Release 2023.1 (January 2023)
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