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Literature summary for 2.4.2.8 extracted from

  • Garozzo, R.; Sortino, M.A.; Vancheri, C.; Condorelli, D.F.
    Antiproliferative effects induced by guanine-based purines require hypoxanthine-guanine phosphoribosyltransferase activity (2010), Biol. Chem., 391, 1079-1089.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
C32-TG cell amelanotic human melanoma cell, hypoxanthine phosphoribosyltransferase-negative Homo sapiens
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U-87MG cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function treatment of cells with guanosine and GMP results in statistically significant decreases in cell growth after 48 h and 72 h in the melanoma cell line C32 and in the U-87 glioma cell line. Presence of hypoxanthine blocks the antiproliferative effects. Hypoxanthine phosphoribosyltransferase-negative cell line C32-TG cells completely has lost the inhibitory response to guanine treatment. Hypoxanthine phosphoribosyltransferase silencing by siRNA is able to partially block the guanine-induced antiproliferative effects in U-87 glioma cell lines Homo sapiens