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Literature summary for 2.4.2.8 extracted from

  • Deng, H.; Callender, R.; Schramm, V.L.; Grubmeyer, C.
    Pyrophosphate activation in hypoxanthine-guanine phosphoribosyltransferase with transition state analogue (2010), Biochemistry, 49, 2705-2714.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.8

Crystallization (Commentary)

Crystallization (Comment) Organism
spectral analysis of the crystal structure of the HGPRT/immucillin-G 5'-phosphate/diphosphate complex Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
immucillin-G 5'-phosphate active site contacts in the HGPRT/immucillin-G 5'-phosphate/diphosphate complex, overview Homo sapiens
immucillin-H 5'-phosphate 5'-phosphate binding structure on HGPRT, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 GMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 IMP + diphosphate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P00492
-
-

Reaction

Reaction Comment Organism Reaction ID
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate ordered reaction mechanism. The substrates bind in a functionally ordered fashion, with 5-phospho-alpha-D-ribose 1-diphosphate binding first in the forward direction and IMP or GMP first in the reverse reaction, transition state structure and 5'-phosphate binding structure on HGPRT, overview Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens GMP + diphosphate
-
 r
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens IMP + diphosphate
-
 r
additional information The substrates bind in a functionally ordered fashion, with 5-phospho-alpha-D-ribose 1-diphosphate binding first in the forward direction and IMP or GMP first in the reverse reaction, transition state structure and 5'-phosphate binding structure on HGPRT, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HGPRT
-
 Homo sapiens
hypoxanthine-guanine phosphoribosyltransferase
-
 Homo sapiens