Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.8 extracted from

  • Dovey, H.F.; McKerrow, J.H.; Aldritt, S.M.; Wang, C.C.
    Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy (1986), J. Biol. Chem., 261, 944-948.
    View publication on PubMed
Search for more literature for 2.4.2.8

Cloned(Commentary)

Cloned (Comment) Organism
mouse neuroblastoma hypoxanthine-guanine phosphoribosyltransferase cDNA clone Schistosoma mansoni

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 2 * 64000, SDS-PAGE Schistosoma mansoni
105000
-
 pore gradient electrophoresis Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Schistosoma mansoni

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
9.25
-
 substrate hypoxanthine Schistosoma mansoni
13.25
-
 substrate guanine Schistosoma mansoni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Schistosoma mansoni GMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Schistosoma mansoni IMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 64000, SDS-PAGE Schistosoma mansoni

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Schistosoma mansoni