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Literature summary for 2.4.2.8 extracted from
- Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae (1981), Biochemistry, 20, 4584-4590.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-thioguanine | competitive to hypoxanthine | Saccharomyces cerevisiae |  |
| adenine | - |
Saccharomyces cerevisiae | |
| guanine | competitve against hypoxanthine | Saccharomyces cerevisiae | |
| xanthine | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
hypoxanthine | - |
Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29500 | - |
2 * 29500, SDS-PAGE | Saccharomyces cerevisiae |
| 54500 | 54800 | equilibrium sedimentation analysis, gel filtration | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Saccharomyces cerevisiae | GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Saccharomyces cerevisiae | IMP + diphosphate | - |
? | |
| additional information | no substrate: adenine | Saccharomyces cerevisiae | ? | - |
? | |
| xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | no activity | Saccharomyces cerevisiae | XMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 29500, SDS-PAGE | Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0008 | - |
6-thioguanine | - |
Saccharomyces cerevisiae | |
| 0.004 | - |
guanine | - |
Saccharomyces cerevisiae | |
| 0.14 | - |
adenine | - |
Saccharomyces cerevisiae | |
| 0.14 | - |
xanthine | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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