Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenine | substrate inhibition, 0.08 mM, 50% inhibition in Propositus (HPRT-) and 20% in control(HPRT+) | Homo sapiens | |
AMP | 2 mM, 80% inhibition with Propositus (HPRT-) and 58% in control(HPRT+) | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
adenine | in (HPRT+) | Homo sapiens | |
0.0044 | - |
adenine | in Propositus (HPRT-) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with partial deficiency in hypoxanthine-guanine phosphoribosyltransferase, (HPRT-) (Propositus), and control(HPRT+) | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
APRT | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
half-inactivation time of control(HPRT+): 10 min | Homo sapiens |
60 | - |
half-inactivation time of control(HPRT+): 9 min | Homo sapiens |
70 | - |
complete inactivation of Propositus (HPRT-) after 20 min, complete inactivation of control(HPRT+) after 10 min | Homo sapiens |
80 | - |
complete inactivation of Propositus (HPRT-) after 13 min, complete inactivation of control(HPRT+) after 7 min | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
AMP | in Propositus (HPRT-) | Homo sapiens | |
0.22 | - |
AMP | in (HPRT+) | Homo sapiens |