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Literature summary for 2.4.2.7 extracted from

  • Crespillo, J.; Llorente, P.; Argomaniz, L.; Montero, C.
    APRT from erythrocytes of HGPRT deficient patients: kinetic, regulatory and thermostability properties (2003), Mol. Cell. Biochem., 254, 359-363.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
adenine substrate inhibition, 0.08 mM, 50% inhibition in Propositus (HPRT-) and 20% in control(HPRT+) Homo sapiens
AMP 2 mM, 80% inhibition with Propositus (HPRT-) and 58% in control(HPRT+) Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
adenine in (HPRT+) Homo sapiens
0.0044
-
adenine in Propositus (HPRT-) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with partial deficiency in hypoxanthine-guanine phosphoribosyltransferase, (HPRT-) (Propositus), and control(HPRT+)
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
APRT
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
half-inactivation time of control(HPRT+): 10 min Homo sapiens
60
-
half-inactivation time of control(HPRT+): 9 min Homo sapiens
70
-
complete inactivation of Propositus (HPRT-) after 20 min, complete inactivation of control(HPRT+) after 10 min Homo sapiens
80
-
complete inactivation of Propositus (HPRT-) after 13 min, complete inactivation of control(HPRT+) after 7 min Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.15
-
AMP in Propositus (HPRT-) Homo sapiens
0.22
-
AMP in (HPRT+) Homo sapiens